A postdoctoral position is available in the laboratory of Samuel W. Brady. The lab focuses on identifying and therapeutically targeting key dependencies in pediatric solid tumors (Banu et al., Science Advances 12:eaeb3503 (2026) http://www.science.org/doi/10.1126/sciadv.aeb3503 and cancer genomics, including mutational signatures (Brady et al., Cancer Discovery 2026 http://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-25-0231/783733/Therapy-related-mutational-signatures-in. Project Description: This position involves the experimental study of key pediatric cancer dependencies, and the identification of new approaches to target them therapeutically. This includes studies of protein signaling, subcellular relocalization, pharmacological studies …

The Hillman Lab, within the newly formed Department of Imaging Sciences at St Jude Children’s Research Hospital is seeking motivated post-doctoral scientists and engineers interested in the development and application of advanced optical imaging and microscopy methods. Project Description The Hillman Lab brings together researchers from physics, engineering, and biology in a collaborative and intellectually open environment. We are driven to connect technology development with meaningful biological insights, aligning with the research and clinical missions of St Jude. Candidates with …

A postdoctoral research associate position is available in the Department of Biostatistics. As a fellow you will join our faculty in the Department of Biostatistics and work closely with a biostatistics faculty collaborating with the Childhood Cancer Survivorship Program (CCSP). You will develop innovative biostatistical methods for childhood cancer survivorship research and collaborate with CCSP investigators. Biostatistics methods will include complex survival analysis, longitudinal analysis, machine learning, and causal inference. You will benefit from access to unique datasets and expertise …

Immunology postdoctoral positions are available in Dr. Hongbo Chi‘s laboratory in the Department of Immunology at St. Jude Children’s Research Hospital. Project Description The Chi lab investigates immunobiology, immunometabolism and cancer immunology, by focusing on metabolic regulation of the immune system and the therapeutic impacts on cancer and other diseases. As metabolic pathways are inextricably connected to immunity and cancer, understanding these connections allows us to gain new insights into biological concepts and disease targets. We are particularly interested in …

A wet-lab postdoctoral position is available immediately in the Northcott Lab (Department of Developmental Neurobiology) to join a highly collaborative team studying the developmental and molecular basis of the childhood brain tumor medulloblastoma. The Northcott Lab has established an internationally renowned track record in pediatric neuro-oncology, substantiated by numerous impactful publications in Nature, Cancer Cell, Nature Cancer, Lancet Oncology, and Journal of Clinical Oncology. Leveraging our exquisite access to patient material linked to large clinical trial cohorts, we are applying …

A postdoc position is available in the lab of Taosheng Chen. The Chen Lab is seeking a Postdoctoral Research Associate to work in a multidisciplinary team to study the regulation of PXR and CAR, or CYP3A4 and CYP3A5, by characterizing novel chemical probes (i.e., small molecule inhibitors or degraders) in biochemical/biophysical, cellular and animal models. Drug toxicity and resistance are the leading causes of therapeutic failures. The Chen Lab (https://www.stjude.org/research/labs/chen-lab-taosheng.html) studies: (1) the chemical regulation of nuclear xenobiotic receptors, (2) …

The Yang laboratory at the Center of Excellence for Structural Cell Biology at St Jude Children’s Research Hospital invites applications for a Postdoctoral Research Associate (Ph.D. level). Project Description: The group specializes in in situ cryo-ET and development of correaltive tools and workflows (Yang et al. J Struct Biol. 2021, Yang et al. Nat Methods 2023, Yang et al. Nat Protoc. 2025, Yang et al. bioRix. 2024). We seek a highly motivated individual interested in studying cell-cell interactions while developing …

The Peijun Ma Laboratory at St. Jude Children’s Research Hospital is seeking a highly motivated Computational Postdoctoral Researcher to develop and apply computational approaches for bacterial genomics, transcriptomics, and single-cell genomics. Project Description:Our research focuses on understanding bacterial heterogeneity, antibiotic responses, host-pathogen interactions, and microbiome dynamics. A major goal of the lab is to bridge bacterial genomics with transcriptomics to uncover how genetic variation, genome architecture, and cellular states shape bacterial behavior and adaptation. The successful candidate will have the …

A Postdoctoral Research Associate position is available in the laboratory of Dr. Yuuta Imoto in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital. The Imoto lab uses super-resolution microscopy and electron-microscopy to investigate rapid synaptic organelle dynamics during neurotransmission. The Fellow will design and conduct experiments aimed at identifying molecular mechanisms by which endocytic structures remove damaged proteins in human physiology and neurodegenerative disorders. Successful candidates will have: A PhD in cell biology, neuroscience, or related discipline …